Which antibody is associated with drug-induced lupus?

Which antibody is associated with drug-induced lupus?

• A. Anti-histone
• B. Anti-dsDNA
• C. Anti-Smith
• D. Anti-RNP

Answer: (A)

Drug-induced lupus is best recognized by the presence of antihistone antibodies. This antibody pattern is classic for DIL, reflecting the immune reaction to drug-modified histones, and it helps distinguish DIL from idiopathic SLE, where anti-dsDNA and anti-Smith antibodies are more characteristic and often relate to kidney or CNS involvement. Anti-RNP is associated with mixed connective tissue disease and certain SLE overlaps, not typically drug-induced lupus. So, antihistone antibodies are the most specific clue for the drug-induced form.

Drug-induced lupus is best recognized by the presence of antihistone antibodies. This antibody pattern is classic for DIL, reflecting the immune reaction to drug-modified histones, and it helps distinguish DIL from idiopathic SLE, where anti-dsDNA and anti-Smith antibodies are more characteristic and often relate to kidney or CNS involvement. Anti-RNP is associated with mixed connective tissue disease and certain SLE overlaps, not typically drug-induced lupus. So, antihistone antibodies are the most specific clue for the drug-induced form.