Which hematologic pattern is most consistent with thalassemia?

Which hematologic pattern is most consistent with thalassemia?

• A. Low hematocrit, low MCV, normal iron, normal ferritin
• B. Low hematocrit, low MCV, low iron, low ferritin
• C. Low hematocrit, normal MCV, normal iron, high ferritin
• D. Normal hematocrit, normal MCV, normal iron, normal ferritin

Answer: (A)

Thalassemia typically causes a microcytic, hypochromic anemia with normal iron stores. The hint is low MCV (microcytosis) with a reduced hematocrit, but normal iron and ferritin levels. In contrast, iron deficiency would push iron and ferritin down, and anemia of chronic disease often shows low iron with normal or high ferritin. Because iron stores remain normal while red cells are small, this pattern best fits thalassemia.

Thalassemia typically causes a microcytic, hypochromic anemia with normal iron stores. The hint is low MCV (microcytosis) with a reduced hematocrit, but normal iron and ferritin levels. In contrast, iron deficiency would push iron and ferritin down, and anemia of chronic disease often shows low iron with normal or high ferritin. Because iron stores remain normal while red cells are small, this pattern best fits thalassemia.